Ọnwụnwa ụlọọgwụ

Ebumnuche: Ebumnuche nke ọmụmụ a bụ inyocha profaịlụ pharmacokinetic na pharmacodynamic (PK-PD) nke lispro nke QS-M jet injector na-enweghị agịga na-elekọta na isiokwu ndị China.

Nchọpụta nyocha na ụzọ: A na-eme ihe n'usoro, nke kpuru ìsì, okpukpu abụọ, nke na-agafe agafe.Ewetara ndị ọrụ afọ ofufo iri na asatọ ahụ ike.A na-elekọta Lispro (0.2 nkeji/kg) site na injector jet na-enweghị agịga QS-M ma ọ bụ site na mkpịsị akwụkwọ.Emere ule mkpọ euglycemic nke were awa asaa.Ndị ọrụ afọ ofufo iri na asatọ (ndị nwoke itoolu na ụmụ nwanyị itoolu) ka ewetere n'ọrụ n'ime ọmụmụ ihe a.Usoro nsonye bụ: ndị na-adịghị aṅụ sịga dị afọ 18-40, nwere nrịbama anụ ahụ (BMI) nke 17-24 kg / m2;ndị nwere nyocha biochemical nkịtị, mgbali ọbara, na electrocardiograph;isiokwu ndị bịanyere aka na nkwenye ahụ.Usoro mwepu bụ: ndị nwere ihe nfụkasị insulin ma ọ bụ akụkọ ihe nfụkasị ndị ọzọ;ndị nwere ọrịa na-adịghị ala ala dịka ọrịa shuga, ọrịa obi, imeju ma ọ bụ ọrịa akụrụ.Ewepụrụkwa ndị na-aṅụ mmanya.Kọmiti ụkpụrụ omume nke ụlọ ọgwụ izizi nke Mahadum Ahụike Chongqing kwadoro ọmụmụ ihe ahụ.

Nsonaazụ: Mpaghara buru ibu n'okpuru usoro (AUCs) nke ntinye insulin na ntinye glucose (GIR) n'ime nkeji 20 mbụ mgbe ịgbanye lispro site na injector jet ma e jiri ya tụnyere pen insulin (24.91 ± 15.25 vs. 12.52 ± 7.60 mg). . kg-1, P <0.001 maka AUCGIR,0-20 min; 0.36 ± 0.24 vs. 0.10 ± 0.04 U min L-1, P <0.001 maka AUCINS, 0-20 min).Ngwunye na-enweghị agịga gosipụtara obere oge iji rute mkpokọta insulin (37.78 ± 11.14 vs. 80.56 ± 37.18 min, P <0.001) na GIR (73.24 ± 29.89 vs. 116.18 ± 51.89 min, P = 0.06).Enweghị ọdịiche dị na mkpughe insulin na mmetụta hypoglycemic n'etiti ngwaọrụ abụọ a.Mmechi: Lispro nke QS-M injector na-enweghị agịga na-enye na-ebute mkpughe insulin na mbụ ma dị elu karịa pensụl ochie, yana mmetụta na-eweda ọkwa glucose n'oge yana ike zuru oke.